Liver Research 
What is a Clinical Trial?
Clinical trials are research studies where individuals participate voluntarily to help uncover answers to particular health questions. When conducted with precision, these trials are the most secure and rapid method to discover new treatments and enhance overall health. Key features also include:
- Benefits: Gaining access to new treatments not available to the public.
- Reimbursement for participation may be available.
It is important to note that new therapies offered in clinical trials can come with side effects or risks that have not yet been discovered by medical professionals. Additionally, these treatments may turn out to be less effective or ineffective compared to existing options.
Current Clinical Trials
NorthShore, in Partnership with CRIOH (Clinical Research Institute of Ohio), is offering clinical trials for the following indications:
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a condition characterized by excess fat accumulation in the liver. It is closely related to the epidemic of obesity and diabetes and is often viewed as the liver manifestation of metabolic syndrome. If untreated, it can progress to metabolic-associated steatohepatitis (MASH).
MASH is the most severe form of MASLD and is characterized by liver cell injury (hepatocellular ballooning) and inflammation, ultimately leading to scarring of the liver/fibrosis. MASH is detected, diagnosed, and monitored through liver enzyme tests, blood markers of fibrosis, and by imaging methods and histopathology of liver biopsies.
Upcoming Liver Clinical Trials
- Alcohol associated liver disease (ALD)
- Obesity
Important Contacts
Iryna Kalinina, Certified Nurse Practitioner, Sub-Investigator
Nina Pollard, DrPH, MPH, Clinical Research Lead
Contact Information:
(440) 363-4000